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ABOUT Dr. Yavas

Yalcin Yavas, Ph.D., HCLD (ABB)

 

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About Dr. Yavas In Brief

Dr. Yavas' Track Record of Expertise in Statistics

Dr. Yavas' Graduate Education

Dr. Yavas as Embryologist / Andrologist / HCLD IVF Laboratory Director

Dr. Yavas as Researcher, and Publisher of Scientific Articles

Dr. Yavas as Reviewer for Scientific Journals

Dr. Yavas' Published Scientific Articles & Abstracts

Dr. Yavas' Latest Research Published in Reproductive Biomedicine Online, analyzing CDC / NASS data on 488,351 ART / IVF Cycles from 2010-2014

 


About Dr. Yavas In Brief

Dr. Yavas received his Master of Science (M.S.) degree from Washington State University, Pullman, Washington, and his doctorate (Ph.D.) degree from University of Guelph, Ontario, Canada, both in reproductive physiology (SEE BELOW for details).

He then acquired almost 20 years of extensive experience in ALL aspects of Assisted Reproductive Technologies (ART) / In Vitro Fertilization (IVF), as Embryologist, Andrologist and IVF Laboratory Director, with particular expertise in Intra-cytoplasmic Sperm Injection (ICSI), on which he also designed and performed research studies, and published research articles (SEE BELOW for his published articles).

Dr. Yavas has published many research articles (mostly in the IVF / ART field) in peer-reviewed scientific journals, including Fertility and Sterility, Journal of Assisted Reproduction and Genetics, and Reproductive Biomedicine Online (SEE BELOW for his published articles).

In many of his published research articles, Dr. Yavas not only single-handedly DESIGNED and PERFORMED the research studies but he also single-handedly PERFORMED ALL THE STATISTICAL ANALYSES and WROTE the ARTICLES in their ENTIRETY.

Dr. Yavas has also SERVED as "REVIEWER" for several scientific journals, such as Fertility and Sterility, Journal of Assisted Reproduction and Genetics, Journal of Experimental & Clinical Assisted Reproduction, Archives of Gynecology and Obstetrics, and Advances In Reproductive Sciences. As a "reviewer" for those scientific journals, he made recommendations to authors, including regarding statistical analyses of their data in their submitted manuscripts (SEE BELOW for details).

Dr. Yavas is CERTIFIED as High-complexity Clinical Laboratory Director (HCLD) by the American Board of Bioanalysis (ABB).

He is also LICENSED as Clinical Laboratory Director by the State of Florida both in embryology and andrology.

Dr. Yavas is also the designer and developer of this website.


Dr. Yavas' Track Record of Expertise in Statistics

  1. During his graduate studies, Dr. Yavas took, and passed with excellent grades, THREE STATISTICS COURSES (SEE BELOW for his transcripts), whereas most graduate students only take one statistics course (or two at the most) during their graduate studies.

Dr. Yavas took TWO of those three courses in statistics during his Master of Science (M.S.) study, and ONE during his Ph.D. study.

The statistics course Dr. Yavas took during his Ph.D. study (which he passed with Grade A; see below) involved intensive use of one of the most advanced computer statistics softwares, Statistical Analysis System, by SAS Institute, Cary, NC, WHICH:

Below are the THREE STATISTICS COURSES Dr. Yavas took during his Ph.D. and Master of Science (M.S.) graduate studies.

 

 

CLICK ON IMAGES BELOW TO SEE Dr. Yavas’ actual TRANSCRIPTS showing the above-listed statistics COURSES along with his GRADES (only statistics courses are shown for the sake of clarity).

Ph.D.

TRANSCRIPT

 

Master of Science (M.S.)

TRANSCRIPT

 

Unlike most graduate students who “hated” statistics and found it “intimidating” or “boring,” Dr. Yavas actually enjoyed statistics and developed an affinity for it over the years following his completion of graduate studies. As a result, and unlike most graduate students, Dr. Yavas has never lost touch with his understanding of statistics.

As a matter fact, and unlike most graduate students, Dr. Yavas has never gotten rid of his books, manuals, notes, assignments and quizzes from the statistics courses he took during his M.S. and Ph.D. studies, and has consistently used them as reference for his research studies over the years.

FOR EXAMPLE:

CLICK ON IMAGES BELOW TO SEE the statistics books, manuals and notes Dr. Yavas used when he took Statistics courses during his M.S. and Ph.D. studies.

 

CLICK ON IMAGES BELOW TO SEE some assignments and grades of Dr. Yavas when he took Statistics courses during his M.S. and Ph.D. studies. Also CLICK ON FULL PDF links to see the same documents in their entirety.

 

  1. As a result, and during almost 20 years of his career as HCLD IVF Laboratory Director, Dr. Yavas continued to design, perform and publish many research studies (some single-handedly in their entirety) in the field of IVF / ART (SEE BELOW for Dr. Yavas’ published articles).

  1. Furthermore, in ALL of his published articles, Dr. Yavas single-handedly performed ALL of the statistical analyses (SEE BELOW for Dr. Yavas’ published articles).

  2. As a result of his numerous articles published in those scientific journals in the field of IVF / ART, Dr. Yavas has been often invited by editors of some of those scientific journals to review (i.e., serve as “reviewer”) manuscripts submitted by other authors for publication in those scientific journals. Those scientific journals inviting Dr. Yavas to serve as “reviewer” included Fertility and Sterility, Journal of Assisted Reproduction and Genetics, Journal of Experimental & Clinical Assisted Reproduction, Archives of Gynecology and Obstetrics, and Advances In Reproductive Sciences. As a reviewer for those scientific journals, Dr. Yavas made recommendations to authors, including regarding statistical analyses of their data in their submitted manuscripts (SEE BELOW for details).

SEE BELOW for some examples of LETTERS FROM THOSE JOURNALS’ editors INVITING Dr. Yavas to review manuscripts submitted by other authors.

 

OVER THE YEARS as a researcher, journal "reviewer," and HCLD IVF Laboratory Director, Dr. Yavas has NOTICED TWO THINGS:

  1. When professionals in the field of IVF / ART attempt to statistically analyze their data, often they do NOT analyze them in the right and efficient statistical way, EVEN IF they manage to have their manuscripts published in those scientific journals (which Dr. Yavas noticed while serving as “reviewer” for those journals, or while reading articles published in those journals).

FOR EXAMPLE, SEE Dr. Yavas' COMMENTS HERE PUBLISHED IN "FERTILITY AND STERILITY" FORUM ON STATISTICAL DESIGN / METHOD of the following article published in Fertility and Sterility Journal:

Gaikwad S, Garrido N, Cobo A, Pellicer A, Remohi J. Bed rest after embryo transfer negatively affects in vitro fertilization: a randomized controlled clinical trial. Fertil Steril. 2013 Sep;100(3):729-35. Epub 2013 Jun 10 (PRINT VERSION).

  1. Most IVF / ART centers only, and simply, calculate / tabulate / monitor their outcome rates (arithmetic means) (such as pregnancy rates, fertilization rates and other outcomes; either over all, or within factors such as embryologists, physicians, etc.); and then they visually compare those arithmetic means; and they mistakenly call this “statistics” or “stats.” THIS IS NOT “statistics,” because statistics means not only calculating those arithmetic means of such factors but also, and most importantly, CORRECTING (adjusting) them for ALL the factors involved as well as DETECTING the degrees of differences with “P values” within and among corrected (adjusted) means of such factors.


Dr. Yavas' Graduate Education

Degree

Specialty

University / Department

Diploma (click on images below)

Ph.D. January 1997:

Reproductive Physiology

University of Guelph,

Department of Animal and Poultry Science,

Guelph, Ontario, Canada

(currently Department of Animal Biosciences).

M.S. May 1992:

Reproductive Physiology

Washington State University,

Department of Animal Sciences,

Pullman, WA, USA.

 


Dr. Yavas as Embryologist / Andrologist / HCLD IVF Laboratory Director

Immediately after completion of his graduate studies, Dr. Yavas pursued his career in IVF / ART both as embryologist and andrologist, with almost 20 years of hands-on experience.

Certified as High-complexity Clinical Laboratory Director (HCLD) by the American Board of Bioanalysis (ABB) for about 20 years, Dr. Yavas also served as IVF Laboratory Director (both embryology & andrology) for 14 years.

Click on the image below to view Dr. Yavas' current HCLD Certificate.

 


Dr. Yavas as Researcher, and Publisher of Scientific Articles

Unlike most graduate students whose research and publications are limited to the time period of their graduate studies, Dr. Yavas continued, during his career in the IVF / ART field, to conduct many research studies in that field.

Dr. Yavas has published the results of his research studies in peer-reviewed scientific journals, including Fertility and Sterility, Journal of Assisted Reproduction and Genetics, and Reproductive Biomedicine Online (SEE BELOW for his published articles).

Dr. Yavas has also often presented the results of his research studies at the Annual Meetings of the American Society for Reproductive Medicine as posters (SEE BELOW for some images), which were also published as abstracts in Fertility and Sterility (SEE BELOW for his published abstracts).

In many of his published research articles, he not only single-handedly DESIGNED and PERFORMED the research studies but he also single-handedly PERFORMED ALL THE STATISTICAL ANALYSES and WROTE the ARTICLES in their ENTIRETY.


Dr. Yavas as Reviewer for Scientific Journals

Dr. Yavas has also SERVED as "REVIEWER" for several scientific journals.

As a result of his numerous articles published in scientific journals in the field of IVF / ART, Dr. Yavas has been often invited by editors of some of those scientific journals to review (i.e., serve as “reviewer”) manuscripts submitted by other authors for publication in those scientific journals.

Those scientific journals inviting Dr. Yavas to serve as “reviewer” include Fertility and Sterility, Journal of Assisted Reproduction and Genetics, Journal of Experimental & Clinical Assisted Reproduction, Archives of Gynecology and Obstetrics, and Advances In Reproductive Sciences.

As a reviewer for those scientific journals, Dr. Yavas made recommendations to authors, including regarding statistical analyses of their data in their submitted manuscripts.

CLICK HERE or on the image below to see Fertility and Sterility acknowledgment of Dr. Yavas as reviewer in 2006 (Last Page of Document).

CLICK ON IMAGES BELOW TO SEE some examples of LETTERS FROM THOSE JOURNALS’ editors INVITING Dr. Yavas to review manuscripts submitted by other authors.

MANUSCRIPT 1 MANUSCRIPT 2 MANUSCRIPT 3 MANUSCRIPT 4 MANUSCRIPT 5

Dr. Yavas' Decision as

Reviewer & his Comments

for Fertility & Sterility

Dr. Yavas' Decision as

Reviewer & his Comments

for Fertility & Sterility

Invitation Letter from

Fertility & Sterility

Invitation Letter from

Fertility & Sterility

Invitation Letter from

Advances In

Reproductive Sciences

   

Thank-You Letter from

Fertility & Sterility

Thank-You Letter from

Fertility & Sterility

 

 


Dr. Yavas' Published Research Articles and Abstracts

Dr. Yavas' Research Articles Published in Peer-Reviewed Scientific Journals

(* produced by Dr. Yavas in their entirety, i.e., the research idea was conceived by Dr. Yavas, the study designed by Dr. Yavas, the statistical analysis performed by Dr. Yavas, and the article written by Dr. Yavas) (statistical analysis performed in all by Dr. Yavas)

  1. * 2017. Yavas Y. Curvilinear relationship between age and assisted reproduction technique success: retrospective analyses of US National ART Surveillance System data from 2010‑2014.  Reprod. Biomed. Online 35(6): 657-668 (Dec 2017) (Epub online Aug 15, 2017) (ScienceDirect LINK) (PubMed LINK) (MORE DETAILS).

  2. * 2009. Yavas Y, Selub MR. Ovarian follicular volume and follicular surface area are better indicators of follicular growth and maturation, respectively, than is follicular diameter. Fertil. Steril. 91(4 Suppl):1299-1302 (Apr 2009) (Epub online Mar 18, 2008) (PubMed LINK) (ScienceDirect LINK) (FULL PDF).

  3. * 2004. Yavas Y, Selub MR. Intrauterine insemination (IUI) pregnancy outcome is enhanced by shorter intervals from semen collection to sperm wash, from sperm wash to IUI time, and from semen collection to IUI time. Fertil. Steril. 82(6):1638-1647 (Dec 2004) (PubMed LINK) (ScienceDirect LINK) (FULL PDF).

  4. 2001. Khamsi F, Roberge S, Yavas Y, Lacanna IC, Zhu X, Wong J. Recent discoveries in physiology of insulin-like growth factor-I and its interaction with gonadotropins in folliculogenesis. Endocrine 16(3):151-165 (Dec 2001) (PubMed LINK) (FULL PDF).

  5. * 2001. Yavas Y, Roberge S, Khamsi F, Shirazi P, Endman MW, Wong JC. Performing ICSI using an injection pipette with the smallest possible inner diameter and a long taper increases normal fertilization rate, decreases incidence of degeneration and tripronuclear zygotes, and enhances embryo development. J. Assist. Reprod. Genet. 18(8):426-435 (Aug 2001) (Pubmed LINK) (FULL PDF).

  6. 2001. Khamsi F, Yavas Y, Roberge S, Wong JC, Lacanna IC, Endman M. Intracytoplasmic sperm injection increased fertilization and good-quality embryo formation in patients with non-male factor indications for in vitro fertilization: a prospective randomized study. Fertil. Steril. 75(2):342-347 (Feb 2001) (PubMed LINK) (ScienceDirect LINK) (FULL PDF).

  7. 2001. Khamsi F, Yavas Y, Lacanna IC, Roberge S, Endman M, Wong JC. Exposure of human oocytes to endometrioma fluid does not alter fertilization or early embryo development. J. Assist. Reprod. Genet. 18(2):106-109 (Feb 2001) (PubMed LINK) (FULL PDF).

  8. 2000. Khamsi F, Yavas Y, Roberge S, Lacanna IC, Wong JC, Endman M. The status of controlled prospective clinical trials for efficacy of intracytoplasmic sperm injection in in vitro fertilization for non-male factor infertility. J. Assist. Reprod. Genet. 17(9):504-507 (Oct 2000) (PubMed LINK) (FULL PDF).

  9. 2000. Yavas Y, de Avila DM, Reeves JJ. Effectiveness of norgestomet implants in suppressing ovulation and estrus in heifers varies with stage of estrous cycle when implanted. Can. J. Anim. Sci. 80(4):729-732 (FULL PDF).

  10. 2000. Yavas Y, Walton JS. Induction of ovulation in postpartum suckled beef cows. A Review. Theriogenology 54(1):1-23 (Jul 2000) (PubMed LINK) (ScienceDirect LINK) (FULL PDF).

  11. 2000. Yavas Y, Walton JS. Postpartum acyclicity in suckled beef cows. A Review. Theriogenology 54(1):25-55 (Jul 2000) (PubMed LINK) (ScienceDirect LINK) (FULL PDF).

  12. 1999. Yavas Y, Johnson WH, Walton JS. Modification of follicular dynamics by exogenous FSH and progesterone, and the induction of ovulation using hCG in postpartum beef cows. Theriogenology 52(6):949-963 (Oct 1999) (PubMed LINK) (ScienceDirect LINK) (FULL PDF).

  13. 1999. Khamsi F, Roberge S, Lacanna IC, Wong J, Yavas Y. Effects of granulosa cells, cumulus cells, and oocyte density on in vitro fertilization in women. Endocrine 10(2):161-166 (Apr 1999) (PubMed LINK) (FULL PDF).

  14. 1999. Khamsi F, Roberge S, Yavas Y, Lacanna IC, The BL, Wong J, Endman M. In vitro fertilization and intra-cytoplasmic sperm injection into the oocyte at Toronto Fertility Sterility Institute (14-year evolution of an independent health facility). Annals of The Royal College of Physicians and Surgeons of Canada 32(2):82-86.

  15. 1996. Yavas Y, de Avila DM, Reeves JJ. Trucking stress at breeding does not lower conception rate of beef heifers. Theriogenology 45(3):623-632 (Feb 1996) (PubMed LINK) (ScienceDirect LINK) (FULL PDF).

 

Dr. Yavas' Letter in Scientific Journals

1999. Yavas Y, Roberge S. ICSI Technique - Impact on Fertilization Rate. Fertil. Steril. 71(6):1165 (Jun 1999) (FULL PDF).

 

Dr. Yavas' Research Abstracts Published in Scientific Journals & Presented at Scientific Meetings

  1. 2006. Yavas Y, Selub MR. Ovarian follicular volume and follicular surface area are more accurate indicators of follicular growth and maturation, respectively, than follicular diameter alone. Fertil. Steril. 86(Suppl.2):S398-S399 (abstr.P-715) (FULL PDF).

  2. 2005. Yavas Y, Selub MR. Incubating washed spermatozoa at 37OC rather than keeping at room temperature (20OC) until intrauterine insemination (IUI) time results in higher pregnancy rate. Fertil Steril. 84(Suppl.1):S265-S266 (abstr.P-322) (FULL PDF).

  3. 2004. Yavas Y, Selub MR, and Carmichael, D. The adverse effect of female age on intra-uterine insemination (IUI) pregnancy outcome is more pronounced within donor frozen-thawed sperm IUI cycles than within partner’s fresh sperm IUI cycles regardless of stimulation type. Fertil. Steril. 82(Suppl.2):S218 (abstr.P-235) (FULL PDF).

  4. 2003. Yavas Y, Selub MR, Lefkow H, Carmichael D. Intra-uterine insemination (IUI) outcome is enhanced by shorter intervals from semen collection to sperm wash, from sperm wash to IUI time, and from semen collection to IUI time. Fertil. Steril. 80(Suppl.3):S152-S153(abstr.P-97) (FULL PDF).

  5. 2003. Yavas Y, Selub MR, Lefkow H, Carmichael D. Type of donor frozen sperm does not affect intra-uterine insemination (IUI) outcome. Fertil. Steril. 80(Suppl.3):S168(abstr.P-139) (FULL PDF).

  6. 2003. Yavas Y, Selub MR, Lefkow H, Carmichael D. Ovarian stimulation with human menopausal gonadotropin (hMG) is more effective than clomiphene citrate (CC) in intra-uterine insemination (IUI) using partner’s sperm, but not in IUI using donor frozen sperm. Fertil. Steril. 80(Suppl.3):S168-S169(abstr.P-141) (FULL PDF).

  7. 2000. Khamsi F, Yavas Y, Roberge S, Lacanna IC, Wong JC, Endman M. Mural granulosa cells (as opposed to cumulus oophorus) may produce a factor inhibiting oocyte fertilization and early embryo development in human. 46th Annual Meeting (abstr.TP21). Canadian Fertility and Andrology Society.

  8. 2000. Khamsi F, Yavas Y, Lacanna IC, Roberge S, Endman M, Wong JC. Exposure of human oocytes to endometrioma fluid does not alter fertilization or early embryo development. 46th Annual Meeting (abstr.FP14). Canadian Fertility and Andrology Society.

  9. 2000. Lacanna IC, Khamsi F, Yavas Y, Roberge S, Wong JC, The BL, Endman M. Intracytoplasmic sperm injection increased fertilization and good-quality embryo formation in patients with non-male indications for in vitro fertilization. A prospective randomized study. 46th Annual Meeting (abstr.FP15). Canadian Fertility and Andrology Society.

  10. 2000. Khamsi F, Afzal DN, The L, Wong J, Yavas Y, Endman M. Increasing number of embryos transferred increases pregnancy rate in IVF cycles. 46th Annual Meeting (abstr.FP19). Canadian Fertility and Andrology Society.

  11. 1999. Roberge S, Yavas Y, Nicot-Montalvo L, Gopalasundaram K, Endman M, Khamsi F. Increased DNA synthesis in oocyte-cumulus complexes (OCCs) of rats treated in vivo with an insulin-like growth factor-I (IGF-I) analogue. Fertil. Steril. Suppl. p.S229. (abstr.P-431).

  12. 1998. Yavas Y, Roberge S, Lacanna I, Wong J, Khamsi F, Endman M. Factors that may influence pregnancy rate in an intracytoplasmic sperm injection (ICSI) program. 44th Annual Meeting (abstr.TP5). Canadian Fertility and Andrology Society.

  13. 1998. Yavas Y, Roberge S, Lacanna I, Khamsi F, Wong J. Simplification of IVF. 6. The type of syringe used for oocyte aspiration. 44th Annual Meeting (abstr.FP4). Canadian Fertility and Andrology Society.

  14. 1998. Roberge S, Yavas Y, Shirazi P, Lacanna I, Wong J, Khamsi F. Simplification of IVF. 7. Comparison of human serum albumin purchased commercially versus patient's own serum and comparison of commercially purchased culture medium versus culture medium produced on site. 44th Annual Meeting (abstr.FP5). Canadian Fertility and Andrology Society.

  15. 1998. Roberge S, Yavas Y, Shirazi P, Khamsi F. Effect of ovarian stimulation type on pregnancy outcome in therapeutic donor insemination program. 44th Annual Meeting (abstr.FP21). Canadian Fertility and Andrology Society.

  16. 1997. Khamsi F, Roberge S, Rouleau A, Yavas Y, Armstrong DT. In vivo infusion with IGF-I analogue, long arg3-insulin-like growth factor-I (LR3-IGF-I), enhances superovulatory response in rats. Fertil. Steril. Suppl. p.S88-S89. (abstr.O-179) (FULL PDF).

  17. 1997. Yavas Y, Roberge S, Shirazi P, Agrawal A, Llano M, Wong J, Lacanna I, Khamsi F. Effects of sperm motility survival rate on fertilization rate in IVF program. 43rd Annual Meeting (abstr.FP33). Canadian Fertility and Andrology Society.

  18. 1997. Roberge S, Yavas Y, Wong J, Lacanna I, Khamsi F. Effects of different ovarian stimulation protocols for IVF on cumulus size, estradiol peak and fertilization rate. 43rd Annual Meeting (abstr.TP13). Canadian Fertility and Andrology Society.

  19. 1997. Roberge S, Rouleau A, Yavas Y, Armstrong DT, Khamsi F. Increased ovarian stimulation of rats infused with IGF-I analogue, long arg3-insulin-like growth factor-I (LR3-IGF-I). 43rd Annual Meeting (abstr.FP8). Canadian Fertility and Andrology Society.

  20. 1997. Roberge S, Yavas Y, Wong J, Lacanna I, Khamsi F. Cost effectiveness of seeking accreditation of a reproductive laboratory by the College of American Pathologists. 43rd Annual Meeting (abstr.FP32). Canadian Fertility and Andrology Society.

  21. 1995. Yavas Y, Roberge S, Buhr MM, Johnson W, Liptrap RM, Walton JS. Effect of gonadotropins and progesterone on follicular dynamics and ovulation in postpartum beef cows. J. Anim. Sci. 73(Suppl.1):235(abstr.485).

  22. 1994. Yavas Y, Roberge S, Buhr MM, Johnson W, Liptrap RM, Walton JS. Effects of FSH, bST and progesterone on follicular dynamics in postpartum suckled beef cows. Biol. Reprod. 50(Suppl.1):64(abstr.40).

  23. 1992. Yavas Y, Reeves JJ. Stress at breeding does not lower conception rates of heifers. J. Anim. Sci. 70(Suppl.1):254(abstr.466).


Images of some posters prepared and presented by Dr. Yavas.

Dr. Yavas presenting posters of his abstracts at 59th Annual Meeting of the American Society for Reproductive Medicine. October 13-15, 2003. San Antonio, Texas (the first three images below). and at 61st Annual Meeting of the American Society for Reproductive Medicine. October 17-19, 2005. Montreal, Canada (the last image below).

Please click on the small pictures below for a slideshow.

.

 

 

 


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